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Nucleic Acid Based Therapeutics Report

: Analysis on the Market, Trends, and Technologies
3.7K
TOTAL COMPANIES
Widespread
Topic Size
Incremental
ANNUAL GROWTH
Surging
trending indicator
312.0B
TOTAL FUNDING
Maturing
Topic Maturity
Hyped
TREND HYPE
N/A
Monthly Search Volume
Published: September 23, 2025
Updated: September 29, 2025
Author: Thomas Ryan

The global nucleic acid–based therapeutics sector is entering a maturing phase marked by platform consolidation and targeted delivery innovation. The market is poised to expand to USD 12.46 billion by 2030 at a 14.29% CAGR, driven by growing investments and clinical successes in RNA and DNA modalities (Nucleic Acid Based Therapeutics Market Size, Share & Trends Analysis Report By Product, By Application, By End-user, By Region, And Segment Forecasts, 2022 To 2030). Over 3,431 companies are active in this field, underscoring widespread industry engagement across discovery, manufacturing, and clinical development. Key growth drivers include the rise of personalized medicine, expansion into extrahepatic tissues, and integration of artificial intelligence into target identification and delivery design.

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Topic Dominance Index of Nucleic Acid Based Therapeutics

To gauge the impact of Nucleic Acid Based Therapeutics, the Topic Dominance Index integrates time series data from three key sources: published articles, number of newly founded startups in the sector, and global search popularity.

Dominance Index growth in the last 5 years: -5.64%
Growth per month: -0.1%

Key Activities and Applications

  • Engineering Advanced Delivery Vehicles
    Development of lipid nanoparticles (LNPs), viral vectors (AAV), polymer carriers, and peptide-based systems to achieve tissue-specific targeting and repeated dosing with minimal off-target effects (Antibody-functionalized lipid nanocarriers for RNA-based cancer gene therapy: advances and challenges in targeted delivery).
  • RNA Payload Optimization
    Chemical modifications of mRNA, siRNA, and antisense oligonucleotides (ASOs) to enhance molecular stability, reduce immunogenicity, and extend in vivo duration.
  • Gene Editing and Modulation
    Base editing, prime editing, and RNA editing approaches for precise correction of genetic mutations, pursued by companies advancing CRISPR/Cas and novel nuclease platforms.
  • Clinical Development and Trials
    Execution of Phase I–III trials across indications from rare genetic disorders to oncology and infectious diseases, leveraging accelerated regulatory pathways and orphan-drug incentives.
  • Vaccine and Immunotherapy Applications
    Use of mRNA and DNA platforms to encode antigens for prophylactic and therapeutic vaccines, including personalized cancer vaccines and next-generation infectious-disease prophylaxis.

Technologies and Methodologies

  • Lipid Nanoparticles (LNPs)
    Leading non-viral carriers with tunable ionizable lipids and surface ligands, further refined for targeted biodistribution and reduced immunogenicity.
  • Adeno-Associated Virus (AAV) Vectors
    Engineered capsids for cell-type specificity, immune evasion, and enhanced packaging capacity, applied in gene-replacement and gene-editing therapies.
  • Antisense Oligonucleotide Chemistries
    Next-generation backbones (e.g., phosphorothioates, locked nucleic acids) for precise mRNA degradation and splicing modulation.
  • Gene Editing Platforms
    CRISPR/Cas base editors and prime editors for single-base corrections without double-strand breaks, advancing curative strategies.
  • Peptide Conjugates and AOC Platforms
    Antibody-Oligonucleotide Conjugates (AOCs) and receptor-targeted peptide carriers enabling cell-specific uptake and extrahepatic distribution.

Nucleic Acid Based Therapeutics Funding

A total of 1.3K Nucleic Acid Based Therapeutics companies have received funding.
Overall, Nucleic Acid Based Therapeutics companies have raised $312.0B.
Companies within the Nucleic Acid Based Therapeutics domain have secured capital from 5.7K funding rounds.
The chart shows the funding trendline of Nucleic Acid Based Therapeutics companies over the last 5 years

Funding growth in the last 5 years: -52.65%
Growth per month: -1.24%

Nucleic Acid Based Therapeutics Companies

  • Nuntius Therapeutics
    Leverages proprietary delivery technology, machine learning, and nucleic acid engineering to develop mRNA therapies for oncology, respiratory, and neurodegenerative diseases. Its proprietary platforms focus on improving stability and precise tissue targeting, with early partnerships validating clinical potential.
  • Via Nova Therapeutics
    Focuses on antiviral nucleic acid therapeutics for acute and subacute infections (influenza, rhinovirus, adenovirus), developing novel RNA-based agents to address gaps in effective antiviral treatments. The company’s strategic emphasis on unmet viral indications positions it for rapid clinical translation.
  • Judo Bio
    Pioneers kidney-targeted siRNA delivery using its STRIKE platform (Selectively Targeting RNA Into KidnEy), enabling receptor-mediated uptake into proximal tubule cells. Initial programs aim to inhibit pathogenic solute carriers, addressing systemic and renal diseases with high unmet need.
  • TraffikGene
    Academic spin-out developing peptide-based delivery solutions for diverse nucleic acids (mRNA, siRNA, pDNA) and proteins (Cas9). Its peptide vehicles demonstrate efficient, non-toxic, and extrahepatic targeting in preclinical in vitro and in vivo models.
  • DNA Nanobots
    Applies DNA origami nanostructures for targeted therapeutic delivery, functionalized for chemotherapy, gene therapy, vaccines, and biosensing. Its modular approach pairs nucleic acid scaffolds with active payloads, aiming to improve precision and minimize off-target exposure.

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3.7K Nucleic Acid Based Therapeutics Companies

Discover Nucleic Acid Based Therapeutics Companies, their Funding, Manpower, Revenues, Stages, and much more

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Nucleic Acid Based Therapeutics Investors

TrendFeedr’s Investors tool offers comprehensive insights into 5.1K Nucleic Acid Based Therapeutics investors by examining funding patterns and investment trends. This enables you to strategize effectively and identify opportunities in the Nucleic Acid Based Therapeutics sector.

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5.1K Nucleic Acid Based Therapeutics Investors

Discover Nucleic Acid Based Therapeutics Investors, Funding Rounds, Invested Amounts, and Funding Growth

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Nucleic Acid Based Therapeutics News

TrendFeedr’s News feature provides access to 25.7K Nucleic Acid Based Therapeutics articles. This extensive database covers both historical and recent developments, enabling innovators and leaders to stay informed.

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25.7K Nucleic Acid Based Therapeutics News Articles

Discover Latest Nucleic Acid Based Therapeutics Articles, News Magnitude, Publication Propagation, Yearly Growth, and Strongest Publications

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Executive Summary

Nucleic acid therapeutics have transitioned from discovery to execution, with delivery excellence emerging as the decisive competitive edge. Established firms refine LNP and AAV platforms, while specialized startups address extrahepatic targeting and novel RNA modalities. Artificial intelligence and bioinformatics are accelerating target discovery and payload design, enabling personalized, combination therapies. Strategic emphasis on platform scalability, regulatory navigation, and supply-chain resilience will define leadership. For stakeholders, aligning investments with delivery-centric platforms and AI-driven discovery engines promises the greatest returns as the field scales toward mainstream clinical adoption.

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